What's your "Ice-breaker"?

Often times we meet people and striking a lovely conversation becomes important.  It's indeed tricky meeting new people.This is because you don't know what to expect from them- there do's and don'ts. 

Oh!!! just if you are wondering what I meant initially,simple, What's your "pick-up" line or how do you initiate a conversation?

To some persons this may not be an issue to others it's really a big deal. You could begin with current issues and happenings.Some persons begin talking by asking simple questions like "What brings you to this part of town?", "what do you do?" and so on. This may work for some but it may be a turn-off for others. Let us know, What is your own Ice-breaker?